Go to MYRIDE.COM for more car videos. Upon introduction, the E350 Sedan is equipped with a standard 3.5-liter, V6, 268-horsepower engine that achieves 19-mpg in the city and 27-mpg on the highway. A 7-speed automatic transmission with overdrive is standard, and a 5-speed automatic transmission with overdrive is optional. The 2006 Mercedes-Benz E-Class is a carryover from 2005.